The Data Management and Analysis Core (DMAC) plays a critical role in achieving the Center objectives by serving as a central repository of Center data and providing for cross-indexing and linkage of the diverse data sets produced by the environmental and biomedical projects and cores in the Center. The DMAC is responsible for the reliability of the data, including cleaning, replication and backup, as well as the protection of the data, including de-identification of human subjects, and secure and authenticated access. The DMAC allows data generated by the projects to be cross-indexed by all projects based on a global PROTECT Data Dictionary that includes common index fields (subject ID, GIS coordinates) to foster sharing and integration. DMAC also provides a rich set of modeling and statistical analysis toolsets and expertise to support Project-level objectives. The combined collection of data and tools allows PROTECT to work seamlessly across project domains and effectively tie environmental factors to human subject outcomes.